Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0LK8O
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| Former ID |
DIB000860
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| Drug Name |
Lifarizine
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| Synonyms |
BANM; Lifarizine hydrochloride < Rec INNM; RS-87476; 1-(Diphenylmethyl)-4-[5-methyl-2-(4-methylphenyl)-1H-imidazol-4-ylmethyl]piperazine trihydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Nerve injury [ICD-11: ND56.4; ICD-10: T14.4] | Discontinued in Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C29H32N4
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| Canonical SMILES |
CC1=CC=C(C=C1)C2=NC(=C(N2)C)CN3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5
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| InChI |
1S/C29H32N4/c1-22-13-15-26(16-14-22)29-30-23(2)27(31-29)21-32-17-19-33(20-18-32)28(24-9-5-3-6-10-24)25-11-7-4-8-12-25/h3-16,28H,17-21H2,1-2H3,(H,30,31)
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| InChIKey |
HTDFEXRUDGWNHA-UHFFFAOYSA-N
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| CAS Number |
119514-66-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium channel unspecific (CaC) | Target Info | Blocker | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003892) | |||
| REF 2 | The effect of lifarizine (RS-87476), a novel sodium and calcium channel modulator, on ischaemic dopamine depletion in the corpus striatum of the gerbil. Br J Pharmacol. 1993 May;109(1):175-7. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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