Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0LR0R
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| Former ID |
DAP001070
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| Drug Name |
Methdilazine
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| Synonyms |
Disyncram; Methdilazinum; Methodilazine; Metodilazina; Tacaryl; Tacazyl; Tacryl; Methilazine hydrochloride; Methdilazine (INN); Methdilazinum [INN-Latin]; Metodilazina [INN-Spanish]; Tacaryl (TN); Methdilazine [USAN:INN:BAN]; 10-((1-Methyl-3-pyrrolidinyl)methyl)phenothiazine; 10-((1-methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine; 10-[(1-Methylpyrrolidin-3-yl)methyl]phenothiazine; 10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine
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| Drug Type |
Small molecular drug
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| Indication | Allergic rhinitis [ICD-11: CA08.0] | Approved | [1], [2] | |
| Therapeutic Class |
Antihistamines
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| Structure |
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Download2D MOL |
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| Formula |
C18H20N2S
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| Canonical SMILES |
CN1CCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
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| InChI |
1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3
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| InChIKey |
HTMIBDQKFHUPSX-UHFFFAOYSA-N
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| CAS Number |
CAS 1982-37-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9384, 135654, 647047, 7593023, 8161076, 10319677, 10512529, 11405746, 14751550, 29282717, 46505472, 47206710, 48035414, 48259508, 48416241, 49855141, 57328680, 79551326, 85209817, 103770942, 104335139, 117404375, 128111044, 131342044, 134338327, 134982817, 137101853, 141522707, 160964241, 176262319, 178103805, 179116778, 184528625, 223440310, 224019337, 226492957, 249964340
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| ChEBI ID |
CHEBI:6823
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| SuperDrug ATC ID |
R06AD04
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| SuperDrug CAS ID |
cas=001982372
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H1 receptor (H1R) | Target Info | Antagonist | [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7231). | |||
| REF 2 | Drug information of Methdilazine, 2008. eduDrugs. | |||
| REF 3 | Effect of H1 blockers alone and in combination with morphine to produce antinociception in mice. Neuropharmacology. 1985 Jan;24(1):1-4. | |||
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