Drug Information
Drug General Information | Top | |||
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Drug ID |
D0LX8Z
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Former ID |
DIB008144
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Drug Name |
OCV-101
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Synonyms |
OTS-11101
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Indication | Pancreatic cancer [ICD-11: 2C10] | Phase 2 | [1] | |
Company |
OncoTherapy Science Inc
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Target and Pathway | Top | |||
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Target(s) | Vascular endothelial growth factor receptor 1 (FLT-1) | Target Info | Modulator | [2] |
KEGG Pathway | Ras signaling pathway | |||
Rap1 signaling pathway | ||||
Cytokine-cytokine receptor interaction | ||||
HIF-1 signaling pathway | ||||
Endocytosis | ||||
PI3K-Akt signaling pathway | ||||
Focal adhesion | ||||
Transcriptional misregulation in cancer | ||||
Rheumatoid arthritis | ||||
Pathway Interaction Database | Glypican 1 network | |||
HIF-2-alpha transcription factor network | ||||
S1P3 pathway | ||||
VEGF and VEGFR signaling network | ||||
VEGFR1 specific signals | ||||
Signaling events mediated by VEGFR1 and VEGFR2 | ||||
Reactome | Neurophilin interactions with VEGF and VEGFR | |||
VEGF binds to VEGFR leading to receptor dimerization | ||||
WikiPathways | Focal Adhesion | |||
Signaling by VEGF | ||||
Angiogenesis |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031248) | |||
REF 2 | Phase I trial of OTS11101, an anti-angiogenic vaccine targeting vascular endothelial growth factor receptor 1 in solid tumor.Cancer Sci.2013 Jan;104(1):98-104. |
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