Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M1UA
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| Former ID |
DIB020295
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| Drug Name |
lysophosphatidylinositol
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| Synonyms |
LPI; L-alpha-lysophosphatidylinositol
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|
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C11H21O12P
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| Canonical SMILES |
CC(=O)OCC(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)O
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| InChI |
1S/C11H21O12P/c1-4(12)21-2-5(13)3-22-24(19,20)23-11-9(17)7(15)6(14)8(16)10(11)18/h5-11,13-18H,2-3H2,1H3,(H,19,20)/t5-,6?,7-,8+,9+,10+,11?/m0/s1
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| InChIKey |
FBDBXJJQMHPGMP-FNFFQOHASA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | G-protein coupled receptor 55 (GPR55) | Target Info | Agonist | [2] |
| Glucose-dependent insulinotropic receptor (GPR119) | Target Info | Agonist | [3] | |
| Transient receptor potential cation channel V2 (TRPV2) | Target Info | Activator | [4] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Insulin secretion | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Incretin Synthesis, Secretion, and Inactivation | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4028). | |||
| REF 2 | Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609. | |||
| REF 3 | Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun. 2005 Jan 28;326(4):744-51. | |||
| REF 4 | Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta. 2009 Mar;1793(3):528-39. | |||
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