Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0M1WN
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| Former ID |
DNC012602
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| Drug Name |
L-701324
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| Synonyms |
L-701324; 142326-59-8; L-701,324; L 701324; UNII-I9WY146163; C21H14ClNO3; L 701,324; CHEMBL31741; 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolone; I9WY146163; 7-Chloro-4-hydroxy-3-(3-pheoxyphenyl)-2(1H)-quinolinone; 2(1H)-Quinolinone, 7-chloro-4-hydroxy-3-(3-pheoxyphenyl)-; SMR000326934; compund 13 [PMID: 8182696]; Tocris-0907; AC1L3GJN; Biomol-NT_000206; MLS002153302; MLS000860076; GTPL4240; SCHEMBL1998890; BPBio1_001264; CHEBI:92140; DTXSID00162016; EX-A587; MolPort-003-941-887; 2(1H)-Quinolinone, 7-chloro-4-hydroxy-3-(3-ph
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| Drug Type |
Small molecular drug
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| Indication | Cerebrovascular ischaemia [ICD-11: 8B1Z; ICD-10: I67.8; ICD-9: 434.91] | Terminated | [1], [2], [3] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H14ClNO3
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| Canonical SMILES |
C1=CC=C(C=C1)OC2=CC=CC(=C2)C3=C(C4=C(C=C(C=C4)Cl)NC3=O)O
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| InChI |
1S/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25)
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| InChIKey |
FLVRDMUHUXVRET-UHFFFAOYSA-N
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| CAS Number |
CAS 142326-59-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6152492, 11113780, 14852666, 24278508, 26751961, 29296662, 46500448, 47734111, 48407477, 50064412, 53859321, 56463203, 57338999, 74478530, 85787790, 91704667, 103202537, 103856997, 103945611, 104397616, 109614211, 124800704, 126433212, 127865846, 134222721, 134349807, 135073053, 135698326, 142472699, 162022759, 162226782, 163772369, 164777554, 170481123, 178101057, 178126151, 179466455, 198983432, 228156678, 241181973, 246643161
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| ChEBI ID |
CHEBI:92140
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| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4240). | |||
| REF 2 | Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex. J Pharmacol Exp Ther. 1996 Nov;279(2):492-501. | |||
| REF 3 | L-701,324, a selective antagonist at the glycine site of the NMDA receptor, counteracts haloperidol-induced muscle rigidity in rats. Psychopharmacology (Berl). 1999 Apr;143(3):235-43. | |||
| REF 4 | Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. | |||
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