Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0M6VZ
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| Former ID |
DIB018055
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| Drug Name |
(-)-englerin A
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| Synonyms |
Englerin A; (-)-englerin A; CHEBI:72441; (1R,3aR,4S,5R,7R,8S,8aR)-5-(glycoloyloxy)-7-isopropyl-1,4-dimethyldecahydro-4,7-epoxyazulen-8-yl (2E)-3-phenylacrylate; GTPL8372; SCHEMBL12280306
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C26H34O6
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| Canonical SMILES |
CC1CCC2C1C(C3(CC(C2(O3)C)OC(=O)CO)C(C)C)OC(=O)C=CC4=CC=CC=C4
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| InChI |
1S/C26H34O6/c1-16(2)26-14-20(30-22(29)15-27)25(4,32-26)19-12-10-17(3)23(19)24(26)31-21(28)13-11-18-8-6-5-7-9-18/h5-9,11,13,16-17,19-20,23-24,27H,10,12,14-15H2,1-4H3/b13-11+/t17-,19-,20-,23-,24+,25+,26-/m1/s1
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| InChIKey |
GACOFEKSDCOVMV-RRYXBOBMSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:72441
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Short transient receptor potential channel 4 (TRPC4) | Target Info | Agonist | [2] |
| Short transient receptor potential channel 5 (TRPC5) | Target Info | Agonist | [2] | |
| Panther Pathway | Alzheimer disease-presenilin pathway | |||
| Reactome | TRP channels | |||
| Role of second messengers in netrin-1 signaling | ||||
| WikiPathways | Netrin-1 signaling | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Enantioselective synthesis of (-)-englerins A and B. Angew Chem Int Ed Engl. 2010 May 3;49(20):3517-9. | |||
| REF 2 | (-)-Englerin is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91. | |||
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