Drug Information
Drug General Information | Top | |||
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Drug ID |
D0MA4O
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Drug Name |
Anti-CD20 CAR-T cells
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Drug Type |
CAR T Cell Therapy (Dual specific)
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Indication | Diffuse large B-cell lymphoma [ICD-11: 2A81; ICD-10: C83.3; ICD-9: 200] | Phase 1/2 | [1] | |
Company |
Southwest Hospital, China
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Target and Pathway | Top | |||
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Target(s) | B-lymphocyte surface antigen B4 (CD19) | Target Info | CAR-T-Cell-Therapy(Dual specific) | [1] |
Leukocyte surface antigen Leu-16 (CD20) | Target Info | CAR-T-Cell-Therapy(Dual specific) | [1] | |
KEGG Pathway | Hematopoietic cell lineage | |||
PI3K-Akt signaling pathway | ||||
B cell receptor signaling pathway | ||||
Epstein-Barr virus infection | ||||
Primary immunodeficiency | ||||
NetPath Pathway | IL-7 Signaling Pathway | |||
Panther Pathway | B cell activation | |||
Pathway Interaction Database | BCR signaling pathway | |||
Reactome | PIP3 activates AKT signaling | |||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
WikiPathways | Human Complement System | |||
Signaling by the B Cell Receptor (BCR) | ||||
PIP3 activates AKT signaling | ||||
B Cell Receptor Signaling Pathway | ||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT02737085) the Sequential Therapy of CD19-targeted and CD20-targeted CAR-T Cell Therapy for Diffuse Large B Cell Lymphoma(DLBCL) |
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