Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0ME8Z
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| Former ID |
DNC008106
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| Drug Name |
5-(2-fluorobenzyloxy)quinazoline-2,4-diamine
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| Synonyms |
CHEMBL251427; 5-(2-fluorobenzyloxy)quinazoline-2,4-diamine; SCHEMBL1154761
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H13FN4O
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| Canonical SMILES |
C1=CC=C(C(=C1)COC2=CC=CC3=C2C(=NC(=N3)N)N)F
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| InChI |
1S/C15H13FN4O/c16-10-5-2-1-4-9(10)8-21-12-7-3-6-11-13(12)14(17)20-15(18)19-11/h1-7H,8H2,(H4,17,18,19,20)
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| InChIKey |
SFJOSBAEWKPKPY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal m... J Med Chem. 2008 Feb 14;51(3):449-69. | |||
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