Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0MM6A
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| Former ID |
DIB015110
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| Drug Name |
Coenzyme Q10 analog
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| Synonyms |
Coenzyme Q10 analog (mitochondrial disease); Coenzyme Q10 analog (mitochondrial disease), Edison Pharmaceuticals
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| Indication | Huntington disease [ICD-11: 8A01.10; ICD-10: G10; ICD-9: 294.1, 333.4] | Phase 2 | [1] | |
| Leigh syndrome [ICD-11: 5C53.24; ICD-10: G31.8] | Phase 2 | [2] | ||
| Mitochondrial respiratory chain disease [ICD-11: 5C53.2; ICD-10: E88.8] | Phase 2 | [2] | ||
| Rett syndrome [ICD-11: LD90.4; ICD-10: F84.2] | Phase 2 | [2] | ||
| Company |
Edison Pharmaceuticals Inc
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Quinone reductase 1 (NQO1) | Target Info | Modulator | [3] |
| KEGG Pathway | Ubiquinone and other terpenoid-quinone biosynthesis | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Pathwhiz Pathway | Vitamin K Metabolism | |||
| Pathway Interaction Database | Validated transcriptional targets of TAp63 isoforms | |||
| WikiPathways | Estrogen metabolism | |||
| Oxidative Stress | ||||
| Transcriptional activation by NRF2 | ||||
| NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Aryl Hydrocarbon Receptor Pathway | ||||
| Apoptosis-related network due to altered Notch3 in ovarian cancer | ||||
| Metabolism of amino acids and derivatives | ||||
| Aryl Hydrocarbon Receptor | ||||
| Dopamine metabolism | ||||
| Arylhydrocarbon receptor (AhR) signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02352896) Long-Term Safety and Efficacy Evaluation of EPI-743 in Children With Leigh Syndrome. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | Therapeutic strategies for Leber's hereditary optic neuropathy: A current update. Intractable Rare Dis Res. 2013 November; 2(4): 130-135. | |||
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