Drug Information
Drug General Information | Top | |||
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Drug ID |
D0MP7N
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Former ID |
DNC010380
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Drug Name |
NSC-345763
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Synonyms |
NSC-345763; 7-(8-hydroxyquinolin-5-yl)-4,7-dioxoheptanoic acid; NSC345763; AC1L7HSU; CHEMBL597114
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C16H15NO5
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Canonical SMILES |
C1=CC2=C(C=CC(=C2N=C1)O)C(=O)CCC(=O)CCC(=O)O
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InChI |
1S/C16H15NO5/c18-10(4-8-15(21)22)3-6-13(19)11-5-7-14(20)16-12(11)2-1-9-17-16/h1-2,5,7,9,20H,3-4,6,8H2,(H,21,22)
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InChIKey |
SDIIGLWXEVMFDA-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | DNA [cytosine-5]-methyltransferase (DNMT) | Target Info | Inhibitor | [1] |
DNA [cytosine-5]-methyltransferase 3B (DNMT3B) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Cysteine and methionine metabolism | |||
Metabolic pathways | ||||
MicroRNAs in cancer | ||||
Reactome | PRC2 methylates histones and DNA | |||
NoRC negatively regulates rRNA expression | ||||
DNA methylation | ||||
WikiPathways | Mesodermal Commitment Pathway | |||
Endoderm Differentiation | ||||
Trans-sulfuration and one carbon metabolism | ||||
One Carbon Metabolism | ||||
miR-targeted genes in lymphocytes - TarBase |
References | Top | |||
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REF 1 | Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. |
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