Drug Information
Drug General Information | Top | |||
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Drug ID |
D0N0FA
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Drug Name |
PMID25435285-Compound-51
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Drug Type |
Small molecular drug
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Company |
F. HOFFMANN-LA ROCHE AG GATTI MCARTHUR, Silvia WICHMANN, Juergen WOLTERING, Thomas
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Structure |
Download2D MOL |
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Formula |
C21H12F6N6
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Canonical SMILES |
C1=CC(=NC=C1C2=CC(=NC(=N2)C3=CC(=NC=C3)C4=CN=C(C=C4)N)C(F)(F)F)C(F)(F)F
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InChI |
1S/C21H12F6N6/c22-20(23,24)16-3-1-13(9-30-16)15-8-17(21(25,26)27)33-19(32-15)11-5-6-29-14(7-11)12-2-4-18(28)31-10-12/h1-10H,(H2,28,31)
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InChIKey |
XWOLECIBHRHRCW-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Metabotropic glutamate receptor 2 (mGluR2) | Target Info | Antagonist | [1] |
Target's Patent Info | Metabotropic glutamate receptor 2 (mGluR2) | Target's Patent Info | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Glutamatergic synapse | ||||
Cocaine addiction | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Ionotropic glutamate receptor pathway | ||||
Metabotropic glutamate receptor group II pathway | ||||
Reactome | G alpha (i) signalling events | |||
Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. |
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