Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N1BC
|
|||
| Former ID |
DNC001206
|
|||
| Drug Name |
Reveromycin A
|
|||
| Drug Type |
Small molecular drug
|
|||
| Structure |
 |
Download2D MOL
|
||
| Formula |
C36H52O11
|
|||
| Canonical SMILES |
CCCCC1(CCC2(CCC(C(O2)CC=C(C)C=CC(C(C)C=CC(=O)O)O)C)OC1C=CC(=CC(=O)O)C)OC(=O)CCC(=O)O
|
|||
| InChI |
1S/C36H52O11/c1-6-7-19-35(47-34(44)17-16-32(40)41)21-22-36(46-30(35)14-10-25(3)23-33(42)43)20-18-27(5)29(45-36)13-9-24(2)8-12-28(37)26(4)11-15-31(38)39/h8-12,14-15,23,26-30,37H,6-7,13,16-22H2,1-5H3,(H,38,39)(H,40,41)(H,42,43)/b12-8+,14-10+,15-11+,24-9+,25-23+/t26-,27-,28-,29+,30-,35+,36-/m0/s1
|
|||
| InChIKey |
ZESGNAJSBDILTB-OXVOKJAASA-N
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Isoleucyl-tRNA synthetase (Bact ileS) | Target Info | Inhibitor | [1], [2] |
| Isoleucyl-tRNA synthetase (IARS) | Target Info | Inhibitor | [3] | |
| BioCyc | TRNA charging | |||
| KEGG Pathway | Aminoacyl-tRNA biosynthesis | |||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| WikiPathways | tRNA Aminoacylation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Chemical modification of reveromycin A and its biological activities. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3363-6. | |||
| REF 2 | Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A. J Biol Chem. 2002 Aug 9;277(32):28810-4. | |||
| REF 3 | Synthesis and biological activities of reveromycin A and spirofungin A derivatives. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3756-60. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.