Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N2CN
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| Former ID |
DNC011679
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| Drug Name |
GR-175737
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| Synonyms |
GR-175737; CHEMBL276798; GR 175737; SCHEMBL195040; GTPL1243; BDBM50070213; 3-[(4-chlorophenyl)methyl]-5-[2-(3H-imidazol-4-yl)ethyl]-1,2,4-oxadiazole; GR175737; L015003; 3-(4-Chloro-benzyl)-5-[2-(1H-imidazol-4-yl)-ethyl]-[1,2,4]oxadiazole; 1,2,4-Oxadiazole, 3-((4-chlorophenyl)methyl)-5-(2-(1H-imidazol-4-yl)ethyl)-; 203874-78-6
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C14H13ClN4O
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| Canonical SMILES |
C1=CC(=CC=C1CC2=NOC(=N2)CCC3=CN=CN3)Cl
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| InChI |
1S/C14H13ClN4O/c15-11-3-1-10(2-4-11)7-13-18-14(20-19-13)6-5-12-8-16-9-17-12/h1-4,8-9H,5-7H2,(H,16,17)
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| InChIKey |
CPOUJACQGWJJQB-UHFFFAOYSA-N
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| CAS Number |
CAS 176860-26-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8. | |||
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