Drug Information
Drug General Information | Top | |||
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Drug ID |
D0N4ZX
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Former ID |
DNCL002010
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Drug Name |
MK-1029
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Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Phase 2 | [1] |
Target and Pathway | Top | |||
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Target(s) | Prostaglandin D2 receptor (PTGDR) | Target Info | Inhibitor | [2] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Pathwhiz Pathway | Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 | |||
Pathway Interaction Database | Thromboxane A2 receptor signaling | |||
Reactome | Prostanoid ligand receptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Prostaglandin Synthesis and Regulation | |||
GPCRs, Class A Rhodopsin-like | ||||
Small Ligand GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT01624974) Study to Evaluate the Effectiveness and Safety of MK-1029 in the Treatment of Persistent Asthma That is Not Controlled With Montelukast (ML) in Adults (MK-1029-011 AM2). U.S. National Institutes of Health. | |||
REF 2 | Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs. Expert Opin Investig Drugs. 2014 Jan;23(1):55-66. |
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