Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0N6MR
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| Former ID |
DNC004194
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| Drug Name |
1,3-Dihydro-imidazo[4,5-b]quinolin-2-one
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| Synonyms |
CHEMBL98604; 1,3-Dihydro-imidazo[4,5-b]quinolin-2-one; SCHEMBL2014813; BDBM50007220; 1H-Imidazo[4,5-b]quinolin-2(3H)-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H7N3O
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| Canonical SMILES |
C1=CC=C2C(=C1)C=C3C(=N2)NC(=O)N3
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| InChI |
1S/C10H7N3O/c14-10-12-8-5-6-3-1-2-4-7(6)11-9(8)13-10/h1-5H,(H2,11,12,13,14)
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| InChIKey |
BINWKEIURMBREF-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 3A (PDE3A) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Purine metabolism | |||
| cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | cGMP effects | |||
| G alpha (s) signalling events | ||||
| WikiPathways | miR-targeted genes in muscle cell - TarBase | |||
| miR-targeted genes in lymphocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. | |||
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