Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0N7AD
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| Former ID |
DAP001079
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| Drug Name |
Azatadine
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| Synonyms |
Azatadina; Azatadinum; Azatidine; Azatadine maleate; Azatadina [INN-Spanish]; Azatadine (INN); Azatadine [INN:BAN]; Azatadinum [INN-Latin]; 11-(1-Methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine
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| Drug Type |
Small molecular drug
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| Indication | Allergic rhinitis [ICD-11: CA08.0] | Approved | [1], [2] | |
| Therapeutic Class |
Antihistamines
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| Structure |
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Download2D MOL |
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| Formula |
C20H22N2
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| Canonical SMILES |
CN1CCC(=C2C3=CC=CC=C3CCC4=C2N=CC=C4)CC1
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| InChI |
1S/C20H22N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12H,8-11,13-14H2,1H3
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| InChIKey |
SEBMTIQKRHYNIT-UHFFFAOYSA-N
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| CAS Number |
CAS 3964-81-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9976, 6866969, 8164714, 10521526, 14849144, 29287392, 46507958, 48415596, 49846682, 50064764, 50757318, 51091807, 57330489, 85209773, 87350405, 103246343, 104348992, 124894113, 125823507, 126670295, 127310116, 127310117, 129222881, 134221903, 134338336, 134985673, 137002504, 142408412, 144206535, 160964063, 164836026, 170464865, 172849907, 178103696, 179225221, 198960451, 210279291, 210281614, 223669450, 224555094, 226395842, 241076914, 250099142, 252411784, 252477770
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| ChEBI ID |
CHEBI:2946
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| SuperDrug ATC ID |
R06AX09
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| SuperDrug CAS ID |
cas=003964816
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H1 receptor (H1R) | Target Info | Antagonist | [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7119). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017601. | |||
| REF 3 | Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis. Asian Pac J Allergy Immunol. 1990 Dec;8(2):103-7. | |||
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