Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0N7BL
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| Former ID |
DIB012847
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| Drug Name |
UK-240455
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| Synonyms |
UK-212189 (racemate); (aR)-N-(6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-(2-hydroxyethyl)methanesulfonamide
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| Drug Type |
Small molecular drug
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| Indication | Nerve injury [ICD-11: ND56.4; ICD-10: T14.4] | Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H11Cl2N3O5S
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| Canonical SMILES |
CS(=O)(=O)N(CCO)C1=C2C(=CC(=C1Cl)Cl)NC(=O)C(=O)N2
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| InChI |
1S/C11H11Cl2N3O5S/c1-22(20,21)16(2-3-17)9-7(13)5(12)4-6-8(9)15-11(19)10(18)14-6/h4,17H,2-3H2,1H3,(H,14,18)(H,15,19)
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| InChIKey |
BGJHUMNCODFLCH-UHFFFAOYSA-N
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| CAS Number |
CAS 178908-09-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glycine receptor (GlyR) | Target Info | Modulator | [1], [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | Iron uptake and transport | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | UK-315716/UK-240455. Pfizer. Curr Opin Investig Drugs. 2001 Dec;2(12):1737-9. | |||
| REF 2 | Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man. Xenobiotica. 2003 May;33(5):541-60. | |||
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