Drug Information
Drug General Information | Top | |||
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Drug ID |
D0N7BP
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Former ID |
DNC004066
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Drug Name |
Z-Arg-Leu-Val-Agly-Val-Ala-NH2
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C34H57N11O8
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Canonical SMILES |
CC(C)CC(C(=O)NC(C(C)C)C(=O)NNC(=O)NC(C(C)C)C(=O)NC(C)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)OCC1=CC=CC=C1
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InChI |
1S/C34H57N11O8/c1-18(2)16-24(40-28(47)23(14-11-15-38-32(36)37)41-34(52)53-17-22-12-9-8-10-13-22)29(48)42-26(20(5)6)31(50)44-45-33(51)43-25(19(3)4)30(49)39-21(7)27(35)46/h8-10,12-13,18-21,23-26H,11,14-17H2,1-7H3,(H2,35,46)(H,39,49)(H,40,47)(H,41,52)(H,42,48)(H,44,50)(H4,36,37,38)(H2,43,45,51)
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InChIKey |
OILQRSUIXCAKPE-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Cathepsin B (CTSB) | Target Info | Inhibitor | [1] |
Cathepsin K (CTSK) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Lysosome | |||
Osteoclast differentiation | ||||
Toll-like receptor signaling pathway | ||||
Rheumatoid arthritis | ||||
Antigen processing and presentation | ||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
RANKL Signaling Pathway | ||||
IL2 Signaling Pathway | ||||
TCR Signaling Pathway | ||||
Reactome | Collagen degradation | |||
Degradation of the extracellular matrix | ||||
Activation of Matrix Metalloproteinases | ||||
Trafficking and processing of endosomal TLR | ||||
MHC class II antigen presentation | ||||
Assembly of collagen fibrils and other multimeric structures | ||||
WikiPathways | RANKL/RANK Signaling Pathway | |||
Osteoclast Signaling |
References | Top | |||
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REF 1 | Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. |
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