Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N8YJ
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| Drug Name |
PMID28270010-Compound-Figure21-b
|
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| Drug Type |
Small molecular drug
|
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| Indication | Brain metastases [ICD-11: 2D50; ICD-10: C79.3] | Patented | [1] | |
| Company |
PFIZER INC
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C21H19FN6O2
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| Canonical SMILES |
CC1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C
|
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| InChI |
1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
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| InChIKey |
IIXWYSCJSQVBQM-LLVKDONJSA-N
|
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| CAS Number |
CAS 1454846-35-5
|
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:143117
|
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | ALK tyrosine kinase receptor (ALK) | Target Info | Inhibitor | [1] |
| Proto-oncogene c-Ros (ROS1) | Target Info | Inhibitor | [1] | |
| Target's Patent Info | ALK tyrosine kinase receptor (ALK) | Target's Patent Info | [1] | |
| Proto-oncogene c-Ros (ROS1) | Target's Patent Info | [1] | ||
| KEGG Pathway | Non-small cell lung cancer | |||
| WikiPathways | Differentiation Pathway | |||
| Spinal Cord Injury | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. | |||
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