Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0NB2K
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| Drug Name |
Pyrrole derivative 4
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| Synonyms |
PMID26161824-Compound-7
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| Drug Type |
Small molecular drug
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| Indication | Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Patented | [1] | |
| Company |
SANOFI-AVENTIS BARTH, Francis CONGY, Christian JEANJEAN, Audrey RINALDI-CARMONA, Muriell
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| Structure |
 |
Download2D MOL |
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| Formula |
C32H30Cl2N4O4
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| Canonical SMILES |
CN1C(=CC(=C1C2=CC=C(C=C2)OCC(=O)N)C3=C(C=C(C=C3)Cl)Cl)C(=O)N4CCC(CC4)(C5=CC=CC=C5)C(=O)N
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| InChI |
1S/C32H30Cl2N4O4/c1-37-27(30(40)38-15-13-32(14-16-38,31(36)41)21-5-3-2-4-6-21)18-25(24-12-9-22(33)17-26(24)34)29(37)20-7-10-23(11-8-20)42-19-28(35)39/h2-12,17-18H,13-16,19H2,1H3,(H2,35,39)(H2,36,41)
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| InChIKey |
LTDLMCVMMICHRM-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cannabinoid receptor 1 (CB1) | Target Info | Antagonist | [1] |
| Target's Patent Info | Cannabinoid receptor 1 (CB1) | Target's Patent Info | [1] | |
| KEGG Pathway | Rap1 signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | ||||
| Panther Pathway | Endogenous cannabinoid signaling | |||
| Pathway Interaction Database | N-cadherin signaling events | |||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| BDNF signaling pathway | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. | |||
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