Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0NF0W
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| Former ID |
DAP000346
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| Drug Name |
Metixene
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| Synonyms |
Atosil; Contalyl; Dalpan; METHIXENE; Methixart; Methixen; Methyloxan; Metisene; Metixeno; Metixenum; Raunana; Tremaril;Tremarit; Tremonil; Tremoquil; Trest; Methixen [German]; Methixene hydrochloride; Metisene [DCIT]; Metixene hydrochloride; Tremaril hydrochloride; Metixene (INN); Metixene (TN); Metixene [INN:BAN]; Metixeno [INN-Spanish]; Metixenum [INN-Latin]; Methixene (*hydrochloride*); Metixene (*hydrochloride*); Tremonil (*hydrochloride*); 1-Methyl-3-(9H-thioxanthen-9-yl-methyl)piperidine; 1-Methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine; 1-Methyl-3-(thioxanthen-9-ylmethyl) piperidine; 1-Methyl-3-(thioxanthen-9-ylmethyl)-1-piperidine; 1-methyl-3-(thioxanthen-9-ylmethyl)-piperidine hydrochloride; 60 SJ 1977; 60 SJ 1977 (*hydrochloride*); 9-(1'-Methylpiperidine-3'-methyl)thioxanthene
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| Drug Type |
Small molecular drug
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| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Approved | [1], [2] | |
| Therapeutic Class |
Antiparkinson Agents
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| Company |
Norvatis Phamaceuticals Corporation
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H23NS
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| Canonical SMILES |
CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24
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| InChI |
1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3
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| InChIKey |
MJFJKKXQDNNUJF-UHFFFAOYSA-N
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| CAS Number |
CAS 4969-02-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
597385, 4904665, 8152607, 10524143, 11456225, 11466519, 11467639, 11486038, 15346390, 29223273, 46508970, 47348968, 47348969, 47348970, 48242945, 49698520, 50016774, 56394917, 57322172, 78232675, 81041209, 85209813, 85787512, 96024897, 103101341, 104305623, 117404335, 125336116, 128603676, 131281806, 131316191, 131349364, 134222552, 135269467, 138790842, 139915862, 152034467, 160963687, 163111900, 164825746, 164826840, 164830803, 178103806, 179225907, 226515127, 241087958, 250073869, 252237304, 252655906
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| ChEBI ID |
CHEBI:51024
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| SuperDrug ATC ID |
N04AA03
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| SuperDrug CAS ID |
cas=004969022
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides caccae
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Metixene hydrochloride (adjusted p-values: 5.68E-03). | |||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Metixene hydrochloride (adjusted p-values: 6.65E-03). | |||
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Studied Microbe: Bacteroides ovatus
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Metixene hydrochloride (adjusted p-values: 1.09E-04). | |||
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Studied Microbe: Bacteroides thetaiotaomicron
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides thetaiotaomicron was decreased by Metixene hydrochloride (adjusted p-values: 4.78E-05). | |||
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Studied Microbe: Bacteroides uniformis
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Metixene hydrochloride (adjusted p-values: 1.34E-05). | |||
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Studied Microbe: Bacteroides vulgatus
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Metixene hydrochloride (adjusted p-values: 2.28E-06). | |||
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Studied Microbe: Odoribacter splanchnicus
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Metixene hydrochloride (adjusted p-values: 9.95E-04). | |||
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Studied Microbe: Parabacteroides distasonis
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Metixene hydrochloride (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Parabacteroides merdae
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Metixene hydrochloride (adjusted p-values: 4.93E-07). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7232). | |||
| REF 2 | Drug information of Metixene, 2008. eduDrugs. | |||
| REF 3 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 4 | Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease.J Pharmacol Exp Ther.2012 Mar;340(3):595-603. | |||
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