Drug Information
Drug General Information | Top | |||
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Drug ID |
D0NU5Z
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Former ID |
DNC006230
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Drug Name |
1,7,8,9-tetrahydro-1,5-diaza-trindene-4,6-dione
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Synonyms |
CHEMBL201907; 1,7,8,9-tetrahydro-1,5-diaza-trindene-4,6-dione; SCHEMBL2086780; ZINC28569089
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C13H10N2O2
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Canonical SMILES |
C1CC2=C3C(=C4C=CNC4=C2C1)C(=O)NC3=O
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InChI |
1S/C13H10N2O2/c16-12-9-6-2-1-3-7(6)11-8(4-5-14-11)10(9)13(17)15-12/h4-5,14H,1-3H2,(H,15,16,17)
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InChIKey |
NMFHMHLMLQVGMW-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | Inhibitor | [1] |
KEGG Pathway | Base excision repair | |||
NF-kappa B signaling pathway | ||||
Panther Pathway | FAS signaling pathway | |||
Pathway Interaction Database | Integrin-linked kinase signaling | |||
Caspase Cascade in Apoptosis | ||||
Notch-mediated HES/HEY network | ||||
Reactome | Dual Incision in GG-NER | |||
WikiPathways | FAS pathway and Stress induction of HSP regulation | |||
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
Nanoparticle triggered regulated necrosis | ||||
Corticotropin-releasing hormone |
References | Top | |||
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REF 1 | Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. |
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