Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0NW3X
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| Former ID |
DAP000495
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| Drug Name |
Dofetilide
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| Synonyms |
Dofetilida; Dofetilidum; Tikosyn; Xelide; UK 68798; Dofetilida [INN-Spanish]; Dofetilidum [INN-Latin];Tikosyn (TN); UK 68,798; UK-68798; Dofetilide [USAN:BAN:INN]; Tikosyn, UK68798, Dofetilide; UK-68,798; Dofetilide (JAN/USAN/INN); Beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide; N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide; N-(4-{2-[methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide; Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl); 1-(4-methanesulfonamidophenoxy)-2-(N-(4-methanesulfonamidophenethyl)-N-methylamine)ethane; 1-MSPMPE
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| Drug Type |
Small molecular drug
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| Indication | Sinus rhythm disorder [ICD-11: BC9Y; ICD-9: 427] | Approved | [1], [2] | |
| Therapeutic Class |
Antiarrhythmic Agents
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| Company |
Pfizer Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H27N3O5S2
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| Canonical SMILES |
CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
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| InChI |
1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
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| InChIKey |
IXTMWRCNAAVVAI-UHFFFAOYSA-N
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| CAS Number |
CAS 115256-11-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9953, 6866968, 7847713, 7979117, 8194566, 11528674, 12014163, 14832836, 26719840, 26757968, 43127674, 46386638, 46509127, 49681772, 49830467, 50139453, 50845418, 57318136, 81041120, 87350381, 92308504, 92308779, 92719410, 103168841, 103940282, 104253292, 104350198, 117632008, 119526323, 121361247, 124659024, 124757413, 124800159, 125001905, 125164217, 125338634, 126620831, 126658284, 126670949, 128235810, 131295440, 131542548, 134337788, 135028787, 135650201, 135692215, 136946393, 137005478, 140086817, 144115915
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| ChEBI ID |
CHEBI:4681
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| ADReCS Drug ID | BADD_D00701 | |||
| SuperDrug ATC ID |
C01BD04
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| SuperDrug CAS ID |
cas=115256116
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Potassium channel unspecific (KC) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2604). | |||
| REF 2 | New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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