Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0O2EM
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| Former ID |
DAP000184
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| Drug Name |
Nevirapine
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| Synonyms |
NEV; NVP; Viramune; Cahill May Roberts Brand of Nevirapine; Promeco Brand of Nevirapine; BI RG 587; BIRG 0587; BIRG 587; BIRG587; BIRG-0587; BIRG-587; NON-NUCLEOSIDE RT INHIBITOR NEVIRAPINE; Nevirapine & PRO 140; Nevirapine [USAN:INN]; Viramune (TN); Viramune(TM); BI-RG-587; Nevirapine & CD4-IgG; Nevirapine (JAN/USP/INN); Viramune, BI-RG 587, Nevirapine; BI-RG-587 & CD4-IgG; N11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one & CD4-immunoadhesin; 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE; 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one; 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one & PRO 140 (Anti-CCR5 monoclonal antibody); 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one; 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one
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| Drug Type |
Small molecular drug
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| Indication | Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] | Approved | [1] | |
| Therapeutic Class |
Anti-HIV Agents
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| Company |
Boehringer Ingelheim
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| Structure |
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Download2D MOL |
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| Formula |
C15H14N4O
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| Canonical SMILES |
CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4
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| InChI |
1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
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| InChIKey |
NQDJXKOVJZTUJA-UHFFFAOYSA-N
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| CAS Number |
CAS 129618-40-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9472, 500792, 597607, 601303, 819817, 823573, 823576, 826050, 826057, 826059, 826060, 832211, 832214, 833983, 865943, 866527, 5596797, 7847501, 7889356, 7889505, 7980115, 8031304, 8152750, 12014582, 14716699, 14716702, 14872507, 17388862, 24721613, 26718578, 26719643, 29223558, 46386569, 46393424, 46394249, 46506789, 48425381, 49718173, 49856363, 50086444, 50622552, 53789571, 56313692, 56313770, 57322283, 81093307, 85173516, 92308419, 92712790, 93166484
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| ChEBI ID |
CHEBI:63613
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| ADReCS Drug ID | BADD_D01557 | |||
| SuperDrug ATC ID |
J05AG01
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| SuperDrug CAS ID |
cas=129618402
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Nevirapine can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.441; p = 0.006). | |||
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Studied Microbe: Clostridium sp.
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Nevirapine can be metabolized by Clostridium sp. (log2FC = -0.474; p = 0.008). | |||
| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Approved antiretroviral drugs. Antiretroviral Drugs. Company report of AVERT. 2009. | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 3 | HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.Nat Struct Mol Biol.2012 Jan 22;19(2):253-9. | |||
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