Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0O3FG
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| Former ID |
DCL000768
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| Drug Name |
Desvenlafaxine
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| Synonyms |
Norvenlafaxine; Desvenlafaxine (INN); Desvenlafaxine [INN:BAN]; O-Desmethylvenlafaxine; WY 45,233; O-DESMETHYLVENLAFAXINE (ODV); WY-45,233
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| Drug Type |
Small molecular drug
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| Indication | Major depressive disorder [ICD-11: 6A70.3; ICD-10: F32.2] | Approved | [1], [2] | |
| Menopause symptom [ICD-11: GA30.0] | Phase 3 | [1], [3] | ||
| Company |
Wyeth
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| Structure |
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Download2D MOL |
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| Formula |
C16H25NO2
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| Canonical SMILES |
CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
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| InChI |
1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3
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| InChIKey |
KYYIDSXMWOZKMP-UHFFFAOYSA-N
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| CAS Number |
CAS 93413-62-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6721883, 10241237, 14872425, 29304940, 47731323, 47805623, 50065397, 80821498, 91612302, 92729724, 96024490, 99246116, 99443254, 103313826, 103923621, 104360436, 118842251, 125359943, 128454905, 131330684, 134339254, 134339255, 135080249, 135684170, 136352797, 136375566, 137206387, 142340945, 152035730, 160967870, 162140123, 162201456, 162312738, 163123297, 164178123, 164828303, 174477381, 175423896, 178103733, 179293788, 184536742, 185989359, 198991666, 203355733, 204362541, 210279762, 210282085, 223381758, 223448271, 223704725
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| ChEBI ID |
CHEBI:83527
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| ADReCS Drug ID | BADD_D00621 ; BADD_D00622 | |||
| SuperDrug ATC ID |
N06AX23
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Serotonin transporter (SERT) | Target Info | Modulator | [2] |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | 5HT1 type receptor mediated signaling pathway | |||
| 5HT2 type receptor mediated signaling pathway | ||||
| 5HT3 type receptor mediated signaling pathway | ||||
| 5HT4 type receptor mediated signaling pathway | ||||
| WikiPathways | Monoamine Transport | |||
| SIDS Susceptibility Pathways | ||||
| NRF2 pathway | ||||
| Synaptic Vesicle Pathway | ||||
| Serotonin Transporter Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7158). | |||
| REF 2 | 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. | |||
| REF 3 | Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. | |||
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