Drug Information
Drug General Information | Top | |||
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Drug ID |
D0O4IO
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Former ID |
DIB021263
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Drug Name |
ztz240
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Synonyms |
ZTZ240; N-(6-chloropyridin-3-yl)-4-fluorobenzamide; 325457-98-5; N-(6-chloro-3-pyridinyl)-4-fluorobenzenecarboxamide; AC1MWVXA; SCHEMBL5214418; GTPL7668; CHEMBL1454208; cid_3780776; BDBM64871; MolPort-002-886-592; KS-00003O7V; ZINC4106322; AKOS005282280; MS-1427; MCULE-1248614968; N-(6-Chloro-3-pyridyl)-4-fluorobenzamide; KB-276144; N-(6-chloro-3-pyridyl)-4-fluoro-benzamide; N-(6-chloro-3-pyridinyl)-4-fluorobenzamide; VU0409859-1
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C12H8ClFN2O
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Canonical SMILES |
C1=CC(=CC=C1C(=O)NC2=CN=C(C=C2)Cl)F
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InChI |
1S/C12H8ClFN2O/c13-11-6-5-10(7-15-11)16-12(17)8-1-3-9(14)4-2-8/h1-7H,(H,16,17)
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InChIKey |
URPKVELJRWKNQS-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Voltage-gated potassium channel Kv7.2 (KCNQ2) | Target Info | Activator | [2] |
KEGG Pathway | Cholinergic synapse | |||
Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
Reactome | Voltage gated Potassium channels | |||
Interaction between L1 and Ankyrins | ||||
WikiPathways | Potassium Channels | |||
L1CAM interactions |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7668). | |||
REF 2 | Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions. J Biol Chem. 2010 Sep 3;285(36):28322-32. |
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