Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0O4SE
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| Former ID |
DIB013815
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| Drug Name |
Tindamax
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| Synonyms |
Tinidazole (oral), Mission Pharmacal
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Approved | [1], [2] | |
| Company |
Presutti Laboratories
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| Structure |
 |
Download2D MOL |
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| Formula |
C8H13N3O4S
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| Canonical SMILES |
CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C
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| InChI |
1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3
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| InChIKey |
HJLSLZFTEKNLFI-UHFFFAOYSA-N
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| CAS Number |
CAS 148159-84-6
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:63627
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -5.943; p = 0.014). | |||
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Studied Microbe: Bacteroides caccae ATCC 43185
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -5.641; p = 0.034). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -7.879; p = 0.0). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -8.221; p = 0.005). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -6.21; p = 0.029). | |||
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Studied Microbe: Bacteroides finegoldii DSM17565
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -7.325; p = 0.006). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -7.994; p = 0.001). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -7.71; p = 0.001). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -7.543; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -7.527; p = 0.001). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -7.31; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -6.839; p = 0.0). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -7.07; p = 0.04). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -7.401; p = 0.007). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -4.592; p = 0.004). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -7.781; p = 0.004). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -6.933; p = 0.001). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -7.026; p = 0.004). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -7.026; p = 0.006). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -7.753; p = 0.003). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -8.405; p = 0.001). | |||
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Studied Microbe: Bacteroides WH2
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides WH2 (log2FC = -7.053; p = 0.009). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -7.682; p = 0.005). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Odoribacter splanchnicus (log2FC = -7.536; p = 0.003). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -7.688; p = 0.002). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -7.75; p = 0.003). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -7.624; p = 0.001). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Pretovella copri DSM 18205 (log2FC = -7.251; p = 0.012). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis ATCC 15703
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bifidobacterium adolescentis ATCC 15703 (log2FC = -3.211; p = 0.001). | |||
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Studied Microbe: Bifidobacterium breve DSM 20213
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -7.152; p = 0.003). | |||
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Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -7.098; p = 0.002). | |||
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Studied Microbe: Bifidobacterium ruminantium
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bifidobacterium ruminantium (log2FC = -2.021; p = 0.007). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens ATCC25986
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Collinsella aerofaciens ATCC25986 (log2FC = -6.161; p = 0.036). | |||
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Studied Microbe: Collinsella intestinalis DSM 13280
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Collinsella intestinalis DSM 13280 (log2FC = -6.676; p = 0.003). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta ATCC 25559
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -6.418; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Clostridium ramosum DSM 1402
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Clostridium ramosum DSM 1402 (log2FC = -6.756; p = 0.003). | |||
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Studied Microbe: Clostridium spiroforme DSM1552
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -6.977; p = 0.012). | |||
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Studied Microbe: Eubacterium biforme DSM 3989
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -6.845; p = 0.006). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerostipes sp.
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Anaerostipes sp. (log2FC = -6.885; p = 0.007). | |||
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Studied Microbe: Anaerotruncus colihominis DSM 17241
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Anaerotruncus colihominis DSM 17241 (log2FC = -7.078; p = 0.003). | |||
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Studied Microbe: Blautia hansenii DSM20583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Blautia hansenii DSM20583 (log2FC = -6.326; p = 0.005). | |||
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Studied Microbe: Blautia luti DSM 14534
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Blautia luti DSM 14534 (log2FC = -6.668; p = 0.005). | |||
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Studied Microbe: Bryantia formatexigens DSM 14469
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -6.448; p = 0.005). | |||
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Studied Microbe: Clostridium asparagiforme DSM 15981
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -5.946; p = 0.002). | |||
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Studied Microbe: Clostridium difficile 120
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Clostridium difficile 120 (log2FC = -6.338; p = 0.015). | |||
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Studied Microbe: Clostridium hathewayi DSM 13479
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -7.51; p = 0.009). | |||
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Studied Microbe: Clostridium scindens ATCC 35704
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Clostridium scindens ATCC 35704 (log2FC = -6.773; p = 0.03). | |||
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Studied Microbe: Clostridium sp.
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Clostridium sp. (log2FC = -6.625; p = 0.004). | |||
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Studied Microbe: Clostridium sporogenes ATCC 15579
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -6.995; p = 0.003). | |||
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Studied Microbe: Clostridium symbiosum ATCC 14940
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Clostridium symbiosum ATCC 14940 (log2FC = -6.163; p = 0.004). | |||
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Studied Microbe: Coprococcus comes ATCC 27758
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Coprococcus comes ATCC 27758 (log2FC = -7.03; p = 0.005). | |||
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Studied Microbe: Dorea formicigenerans ATCC 27755
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Dorea formicigenerans ATCC 27755 (log2FC = -6.896; p = 0.01). | |||
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Studied Microbe: Enterocloster bolteae ATCC BAA-613
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Enterocloster bolteae ATCC BAA-613 (log2FC = -6.639; p = 0.01). | |||
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Studied Microbe: Eubacterium hallii DSM3353
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Eubacterium hallii DSM3353 (log2FC = -6.863; p = 0.009). | |||
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Studied Microbe: Eubacterium rectale ATCC 33656
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -6.387; p = 0.007). | |||
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Studied Microbe: Eubacterium ventriosum ATCC 27560
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -7.333; p = 0.012). | |||
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Studied Microbe: Roseburia intestinalis L1-82
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Roseburia intestinalis L1-82 (log2FC = -6.134; p = 0.005). | |||
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Studied Microbe: Ruminococcus gnavus ATCC 29149
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Ruminococcus gnavus ATCC 29149 (log2FC = -5.355; p = 0.01). | |||
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Studied Microbe: Ruminococcus lactaris ATCC 29176
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -6.636; p = 0.011). | |||
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Studied Microbe: Ruminococcus torques ATCC 27756
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -7.082; p = 0.005). | |||
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Studied Microbe: Subdoligranulum variabile DSM 15176
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -6.609; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus faecalis V583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Enterococcus faecalis V583 (log2FC = -6.603; p = 0.011). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
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Studied Microbe: Anaerococcus hydrogenalis DSM 7454
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -7.402; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila ATCC BAA-835
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -1.284; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -5.685; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [4] | |||
| Experimental Method | High-throughput screening | |||
| Description | Tinidazole can be metabolized by gut microbiota. | |||
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides caccae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Tinidazole (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Tinidazole (adjusted p-values: 5.91E-06). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Tinidazole (adjusted p-values: 2.61E-05). | |||
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Studied Microbe: Bacteroides ovatus
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Tinidazole (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bacteroides thetaiotaomicron
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides thetaiotaomicron was decreased by Tinidazole (adjusted p-values: 1.43E-05). | |||
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Studied Microbe: Bacteroides uniformis
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Tinidazole (adjusted p-values: 1.32E-06). | |||
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Studied Microbe: Bacteroides vulgatus
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Tinidazole (adjusted p-values: 2.33E-06). | |||
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Studied Microbe: Bacteroides xylanisolvens
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides xylanisolvens was decreased by Tinidazole (adjusted p-values: 2.06E-05). | |||
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Studied Microbe: Odoribacter splanchnicus
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Tinidazole (adjusted p-values: 8.57E-06). | |||
|
Studied Microbe: Parabacteroides distasonis
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Tinidazole (adjusted p-values: 4.87E-06). | |||
|
Studied Microbe: Parabacteroides merdae
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Tinidazole (adjusted p-values: 4.93E-07). | |||
|
Studied Microbe: Prevotella copri
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Tinidazole (adjusted p-values: 4.65E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
|
Studied Microbe: Bifidobacterium longum
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium longum was decreased by Tinidazole (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
|
Studied Microbe: Collinsella aerofaciens
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Tinidazole (adjusted p-values: 3.20E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
|
Studied Microbe: Eggerthella lenta
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eggerthella lenta was decreased by Tinidazole (adjusted p-values: 4.10E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
|
Studied Microbe: Erysipelatoclostridium ramosum
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Tinidazole (adjusted p-values: 6.89E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
|
Studied Microbe: Blautia obeum
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Tinidazole (adjusted p-values: 1.13E-05). | |||
|
Studied Microbe: Clostridioides difficile
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridioides difficile was decreased by Tinidazole (adjusted p-values: 5.06E-06). | |||
|
Studied Microbe: Clostridium perfringens
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Tinidazole (adjusted p-values: 5.51E-07). | |||
|
Studied Microbe: Coprococcus comes
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Tinidazole (adjusted p-values: 8.66E-06). | |||
|
Studied Microbe: Dorea formicigenerans
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Tinidazole (adjusted p-values: 5.27E-06). | |||
|
Studied Microbe: Enterocloster bolteae
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Tinidazole (adjusted p-values: 8.23E-06). | |||
|
Studied Microbe: Eubacterium eligens
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Tinidazole (adjusted p-values: 1.05E-05). | |||
|
Studied Microbe: Eubacterium rectale
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Tinidazole (adjusted p-values: 9.67E-04). | |||
|
Studied Microbe: Lacrimispora saccharolytica
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Tinidazole (adjusted p-values: 5.51E-07). | |||
|
Studied Microbe: Roseburia hominis
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Tinidazole (adjusted p-values: 5.43E-05). | |||
|
Studied Microbe: Roseburia intestinalis
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Tinidazole (adjusted p-values: 6.05E-04). | |||
|
Studied Microbe: Ruminococcus bromii
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Tinidazole (adjusted p-values: 1.62E-05). | |||
|
Studied Microbe: Ruminococcus gnavus
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Tinidazole (adjusted p-values: 5.04E-06). | |||
|
Studied Microbe: Ruminococcus torques
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Tinidazole (adjusted p-values: 1.97E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Veillonellales | ||||
|
Studied Microbe: Veillonella parvula
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Veillonella parvula was decreased by Tinidazole (adjusted p-values: 6.93E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Akkermansia muciniphila was decreased by Tinidazole (adjusted p-values: 6.51E-04). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4. | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
| REF 5 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
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