Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0OB7B
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| Former ID |
DNC009954
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| Drug Name |
2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridine
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| Synonyms |
CHEMBL583693; SCHEMBL12041243; BDBM50299006
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H22N4S
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| Canonical SMILES |
C1CCN(CC1)C2CCN(CC2)C3=NC4=C(S3)C=CC=N4
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| InChI |
1S/C16H22N4S/c1-2-9-19(10-3-1)13-6-11-20(12-7-13)16-18-15-14(21-16)5-4-8-17-15/h4-5,8,13H,1-3,6-7,9-12H2
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| InChIKey |
LHPSMXXBNXLHOD-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and structure-activity relationships of 2-(1,4'-bipiperidin-1'-yl)thiazolopyridine as H3 receptor antagonists. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6176-80. | |||
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