Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0OH2P
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| Former ID |
DIB018097
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| Drug Name |
(S)-(+)-CBPG
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| Synonyms |
CBPG; 3-[(S)-amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid; 180465-02-5; (S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-1-carboxylic acid; CHEMBL43412; S-(+)-CBPG; EN300-88066; (S)-(+)-CBPG; AC1NSJVN; AC1Q4UAL; SCHEMBL1308145; GTPL3421; (R)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-1-carboxylic acid; CTK7I3432; MolPort-044-812-180; MolPort-005-313-665; ZINC1485767; BDBM50052256; AKOS026740795; FCH4013584; AS-44366; OR312475; CS-0078773; KS-00000111; (s)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C8H11NO4
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| Canonical SMILES |
C1C2(CC1(C2)C(=O)O)C(C(=O)O)N
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| InChI |
1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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| InChIKey |
KNSHLWJBSDBBRH-XOJFDHPMSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Metabotropic glutamate receptor 1 (mGluR1) | Target Info | Antagonist | [2] |
| Metabotropic glutamate receptor 5 (mGluR5) | Target Info | Agonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Long-term potentiation | ||||
| Retrograde endocannabinoid signaling | ||||
| Glutamatergic synapse | ||||
| Huntington's disease | ||||
| FoxO signaling pathway | ||||
| Long-term depression | ||||
| Estrogen signaling pathway | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||
| Metabotropic glutamate receptor group III pathway | ||||
| Metabotropic glutamate receptor group I pathway | ||||
| Endogenous cannabinoid signaling | ||||
| Reactome | G alpha (q) signalling events | |||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | Hypothetical Network for Drug Addiction | |||
| GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3421). | |||
| REF 2 | Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity. Neuropharmacology. 1999 Jul;38(7):917-26. | |||
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