Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0OJ7S
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| Former ID |
DIB020981
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| Drug Name |
SR142948A
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| Synonyms |
SR-142948A
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C39H51N5O6
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| Canonical SMILES |
CC(C)C1=C(C=CC(=C1)C(=O)N(C)CCCN(C)C)N2C(=CC(=N2)C(=O)NC3(C4CC5CC(C4)CC3C5)C(=O)O)C6=C(C=CC=C6OC)OC
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| InChI |
1S/C39H51N5O6/c1-23(2)29-21-26(37(46)43(5)15-9-14-42(3)4)12-13-31(29)44-32(35-33(49-6)10-8-11-34(35)50-7)22-30(41-44)36(45)40-39(38(47)48)27-17-24-16-25(19-27)20-28(39)18-24/h8,10-13,21-25,27-28H,9,14-20H2,1-7H3,(H,40,45)(H,47,48)
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| InChIKey |
LWULHXVBLMWCHO-UHFFFAOYSA-N
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| CAS Number |
CAS 184162-64-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7980656, 11056515, 14815074, 39341125, 47731315, 47805619, 50112868, 50569217, 57359486, 85222213, 85788189, 113635343, 114156133, 125762525, 128552765, 134222691, 135651074, 136351150, 137142845, 137275715, 144239952, 162023294, 162223894, 175453055, 194172319, 196376815, 225052837, 233165741, 241375876, 249617535, 252156433, 252159998
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| ChEBI ID |
CHEBI:93589
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neurotensin receptor type 1 (NTSR1) | Target Info | Antagonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1580). | |||
| REF 2 | Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J Pharmacol Exp Ther. 1997 Feb;280(2):802-12. | |||
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