Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0OM5M
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| Former ID |
DIB006060
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| Drug Name |
Ro-48-1220
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Terminated | [1] | |
| Company |
Roche Holding AG
|
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| Structure |
 |
Download2D MOL |
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| Formula |
C10H10N2O5S
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| Canonical SMILES |
CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)O)C=CC#N
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| InChI |
1S/C10H10N2O5S/c1-10(3-2-4-11)8(9(14)15)12-6(13)5-7(12)18(10,16)17/h2-3,7-8H,5H2,1H3,(H,14,15)/b3-2+/t7-,8+,10+/m1/s1
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| InChIKey |
JYGFUXUBGZBBAC-RCRIAUEHSA-N
|
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| CAS Number |
CAS 768335-49-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Staphylococcus Beta-lactamase (Stap-coc blaZ) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004684) | |||
| REF 2 | Comparative in vitro activity of apalcillin alone and combined with Ro 48-1220, a novel penam beta-lactamase inhibitor. Clin Microbiol Infect. 1995 Feb;1(2):86-100. | |||
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