Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0OX9Q
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| Former ID |
DIB014020
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| Drug Name |
NOX-200
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| Synonyms |
2-Amino-3-(1H-indol-3-yl)-2-methylpropanoic acid; alpha-Methyl-DL-tryptophan; 153-91-3; 2-amino-3-(1H-indol-3-yl)-2-methylpropanoic acid; NSC9948; 13510-08-2; alpha-Methyl-L-tryptophan; M-5098; Tryptophan, alpha-methyl-; 16709-25-4; DL-alpha-Methyltryptophan; alpha-methyl-D,L-tryptophan; NSC-9948; NSC 9948; Tryptophan,a-methyl-; ACMC-1BNRO; alpha-Methyltryptophan; AC1L3UBI; AC1Q5S1L; (S)-alpha-Methyl pryptophan; SCHEMBL343309; CHEMBL559578; GTPL4693; CTK4C8033; ZTTWHZHBPDYSQB-UHFFFAOYSA-N; MolPort-003-958-850; KS-000001AA; ANW-21478
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| Drug Type |
Small molecular drug
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| Indication | Rheumatoid arthritis [ICD-11: FA20] | Terminated | [1] | |
| Company |
Medinox Inc
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| Structure |
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Download2D MOL |
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| Formula |
C12H14N2O2
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| Canonical SMILES |
CC(CC1=CNC2=CC=CC=C21)(C(=O)O)N
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| InChI |
1S/C12H14N2O2/c1-12(13,11(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,14H,6,13H2,1H3,(H,15,16)
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| InChIKey |
ZTTWHZHBPDYSQB-UHFFFAOYSA-N
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| CAS Number |
CAS 153-91-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
75299, 7443797, 8138514, 10227287, 10321087, 11446579, 12015774, 15018594, 24897245, 44425950, 48482847, 49748129, 50982757, 57336062, 85087831, 91721630, 103684243, 103852799, 104415467, 117543318, 124557211, 125539935, 129953957, 135267376, 135368052, 142335360, 152048929, 160788979, 162091878, 162270658, 162796351, 164806288, 165441993, 178101406, 179236715, 184538697, 184825841, 204380425, 223701771, 226678430, 249859321, 250225095, 252069282, 252405137
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Amino acid transporter ATB0+ (SLC6A14) | Target Info | Inhibitor | [2] |
| Solute carrier family 36 member 2 (SLC36A2) | Target Info | Inhibitor | [3] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010855) | |||
| REF 2 | Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy. Biochem J. 2008 Sep 15;414(3):343-55. | |||
| REF 3 | Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta. 2011 Jan;1808(1):260-70. | |||
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