Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0P3FZ
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| Former ID |
DNC012930
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| Drug Name |
5-(piperidin-4-yl)isothiazol-3-ol
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| Synonyms |
CHEMBL109209; 5-(piperidin-4-yl)isothiazol-3-ol; Thio-4-PIOL; SCHEMBL2046840; 5-(4-Piperidyl)isothiazole-3-ol; 5-Piperidin-4-yl-isothiazol-3-ol; BDBM50032951; PDSP2_001589
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H12N2OS
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| Canonical SMILES |
C1CNCCC1C2=CC(=O)NS2
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| InChI |
1S/C8H12N2OS/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)
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| InChIKey |
WUINUICOEAZPLK-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1] |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| Iron uptake and transport | ||||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. | |||
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