Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0P3JF
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| Former ID |
DIB010819
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| Drug Name |
SCH-900978
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| Synonyms |
Neurokinin 1 receptor antagonist (emesis), OPKO Health
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| Indication | Cough [ICD-11: MD12; ICD-10: R05; ICD-9: 786.2] | Phase 2 | [1] | |
| Company |
OPKO Health Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H23F6N5O2
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| Canonical SMILES |
CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OCC2(CCC(CN2)(C#N)N3C=NNC3=O)C4=CC=CC=C4
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| InChI |
1S/C25H23F6N5O2/c1-16(17-9-19(24(26,27)28)11-20(10-17)25(29,30)31)38-14-23(18-5-3-2-4-6-18)8-7-22(12-32,13-33-23)36-15-34-35-21(36)37/h2-6,9-11,15-16,33H,7-8,13-14H2,1H3,(H,35,37)/t16-,22-,23-/m1/s1
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| InChIKey |
ACZWFJDLNLZWDP-ZGNKEGEESA-N
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| CAS Number |
CAS 873947-10-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Substance-P receptor (TACR1) | Target Info | Antagonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Measles | ||||
| Panther Pathway | CCKR signaling map ST | |||
| Reactome | G alpha (q) signalling events | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Spinal Cord Injury | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of OPKO Health Inc. | |||
| REF 2 | Clinical pipeline report, company report or official report of OPKO Health, Inc. | |||
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