Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0P9ED
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| Former ID |
DNC007889
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| Drug Name |
CMI-489
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| Synonyms |
CMI-489; CHEMBL291498; HLNPMOXPJPCMLY-UHFFFAOYSA-N; N-methylepibatidine; N-methyl Epibatidine; SCHEMBL10105083; 222/224 N-Methyl-Epibatidine; BDBM50079453; 7-Methyl-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane; 2-(6-Chloro-pyridin-3-yl)-7-methyl-7-aza-bicyclo[2.2.1]heptane
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H15ClN2
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| Canonical SMILES |
CN1C2CCC1C(C2)C3=CN=C(C=C3)Cl
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| InChI |
1S/C12H15ClN2/c1-15-9-3-4-11(15)10(6-9)8-2-5-12(13)14-7-8/h2,5,7,9-11H,3-4,6H2,1H3
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| InChIKey |
HLNPMOXPJPCMLY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuronal acetylcholine receptor alpha-4 (CHRNA4) | Target Info | Inhibitor | [1] |
| Neuronal acetylcholine receptor beta-2 (CHRNB2) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Cholinergic synapse | ||||
| Nicotine addiction | ||||
| Panther Pathway | Nicotinic acetylcholine receptor signaling pathway | |||
| Nicotine pharmacodynamics pathway | ||||
| Reactome | Highly sodium permeable acetylcholine nicotinic receptors | |||
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
| Highly calcium permeable nicotinic acetylcholine receptors | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Nicotine Activity on Dopaminergic Neurons | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine. J Med Chem. 2007 Dec 13;50(25):6383-91. | |||
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