Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0PB6B
|
|||
Former ID |
DIB019746
|
|||
Drug Name |
dimethylhistaprodifen
|
|||
Synonyms |
dimethylhistaprodifen; CHEMBL11553; GTPL1203; BDBM86170; PDSP1_001311; PDSP2_001295; N,N-Dimethyl-2-(3,3-diphenylpropyl)-1H-imidazole-4-(ethanamine)
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
|
|||
Formula |
C22H27N3
|
|||
Canonical SMILES |
CN(C)CCC1=CN=C(N1)CCC(C2=CC=CC=C2)C3=CC=CC=C3
|
|||
InChI |
1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)
|
|||
InChIKey |
GNBOIGBQIBQOIA-UHFFFAOYSA-N
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Histamine H1 receptor (H1R) | Target Info | Agonist | [2] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Inflammatory mediator regulation of TRP channels | ||||
Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
Reactome | Histamine receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
IL-4 Signaling Pathway | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
---|---|---|---|---|
REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1203). | |||
REF 2 | Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.