Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0PG0G
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| Former ID |
DAP000151
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| Drug Name |
Drotrecogin alfa
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| Synonyms |
Xigris; Drotrecogin alfa (activated); Xigris (TN); Drotrecogin alfa (activated) (USAN)
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|
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| Indication | Cerebrovascular ischaemia [ICD-11: 8B1Z; ICD-10: I67.8] | Approved | [1], [2], [3] | |
| Severe sepsis [ICD-11: 1G40-1G41] | Approved | [1], [2], [3] | ||
| Therapeutic Class |
Antisepsis Agents
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| Company |
Eli Lilly
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| PubChem Substance ID | ||||
| SuperDrug ATC ID |
B01AD10
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Coagulation factor Va (F5) | Target Info | Inhibitor | [4] |
| Coagulation factor VIII (F8) | Target Info | Inhibitor | [4] | |
| KEGG Pathway | Complement and coagulation cascades | |||
| Panther Pathway | Blood coagulation | |||
| Pathwhiz Pathway | Coagulation | |||
| Reactome | Platelet degranulation | |||
| Intrinsic Pathway of Fibrin Clot Formation | ||||
| Common Pathway of Fibrin Clot Formation | ||||
| COPII (Coat Protein 2) Mediated Vesicle Transport | ||||
| Cargo concentration in the ER | ||||
| WikiPathways | Complement and Coagulation Cascades | |||
| Blood Clotting Cascade | ||||
| Formation of Fibrin Clot (Clotting Cascade) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6788). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Protein C in critical illness. Am J Health Syst Pharm. 2009 Jun 15;66(12):1089-96. | |||
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