Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Q0OP
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| Former ID |
DIB014981
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| Drug Name |
CAB-2
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| Synonyms |
MLN2222
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| Indication | Coronary artery disease [ICD-11: BA80; ICD-10: I25.1, I25.4] | Discontinued in Phase 1 | [1] | |
| Company |
Millennium Pharmaceuticals
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Complement factor B (CFB) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Complement and coagulation cascades | |||
| Staphylococcus aureus infection | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Reactome | Alternative complement activation | |||
| Activation of C3 and C5 | ||||
| Regulation of Complement cascade | ||||
| WikiPathways | Complement and Coagulation Cascades | |||
| Human Complement System | ||||
| Complement cascade | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010210) | |||
| REF 2 | A soluble chimeric inhibitor of C3 and C5 convertases, complement activation blocker-2, prolongs graft survival in pig-to-rhesus monkey heart transplantation. Xenotransplantation. 2002 Mar;9(2):125-34. | |||
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