Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Q1BT
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| Former ID |
DAP001117
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| Drug Name |
Clidinium
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| Synonyms |
clidinium; N-Methyl quinuclidinyl benzilate; 7020-55-5; 3-hydroxy-1-methylquinuclidinium benzilate ester; 3-{[hydroxy(diphenyl)acetyl]oxy}-1-methyl-1-azoniabicyclo[222]octane; Ro-23773; 3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-methyl-1-azonia-bicyclo[222]octane; 1-Azoniabicyclo(222)octane, 3-((hydroxydiphenylacetyl)oxy)-1-methyl-; [3H]clidinium; (-)MQNB; Clidinium bromid; (1-methyl-1-azoniabicyclo[222]octan-8-yl) 2-hydroxy-2,2-di(phenyl)acetate; 3-Hydroxy-1-methylquinuclidinium benzilate (ester); Quinuclidinium,; Librax (TN); Benzilic acid, ester with 3-hydroxy-1-methylquinuclidinium; Quinuclidinium, 3-hydroxy-1-methyl-, benzilate (ester); (1-methyl-1-azoniabicyclo[222]octan-3-yl) 2-hydroxy-2,2-diphenylacetate
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| Drug Type |
Small molecular drug
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| Indication | Abdominal stomach pain [ICD-11: DD91.4] | Approved | [1], [2], [3] | |
| Irritable bowel syndrome [ICD-11: DD91.0; ICD-10: K55-K64, K58] | Approved | [1], [2], [3] | ||
| Therapeutic Class |
Analgesics
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| Company |
Hoffmann La Roche Inc
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| Structure |
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Download2D MOL |
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| Formula |
C22H26NO3+
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| Canonical SMILES |
C[N+]12CCC(CC1)C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
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| InChI |
1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1
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| InChIKey |
HOOSGZJRQIVJSZ-UHFFFAOYSA-N
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| CAS Number |
CAS 7020-55-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10055, 5527706, 5864563, 7978960, 8151796, 10544421, 11335873, 11361112, 11363050, 11365612, 11368174, 11371367, 11373981, 11376336, 11462084, 11466850, 11467970, 11483904, 11486400, 11487940, 11490170, 11492106, 11493970, 29221939, 46507814, 47291148, 47365199, 47365200, 47589012, 47662296, 48259241, 48334503, 49698978, 50807214, 57321458, 85209725, 96079550, 103188114, 103952426, 104301601, 124883402, 128485066, 134222992, 134338362, 135077135, 135650108, 135651180, 135950079, 137260982, 141696484
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| ChEBI ID |
CHEBI:3743
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Muscarinic acetylcholine receptor (CHRM) | Target Info | Antagonist | [4] |
| Muscarinic acetylcholine receptor M1 (CHRM1) | Target Info | Antagonist | [5] | |
| KEGG Pathway | Calcium signaling pathway | |||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| PI3K-Akt signaling pathway | ||||
| Cholinergic synapse | ||||
| Regulation of actin cytoskeleton | ||||
| Panther Pathway | Alzheimer disease-amyloid secretase pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Muscarinic acetylcholine receptor 1 and 3 signaling pathway | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Muscarinic acetylcholine receptors | |||
| G alpha (q) signalling events | ||||
| Acetylcholine regulates insulin secretion | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| Regulation of Actin Cytoskeleton | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Secretion of Hydrochloric Acid in Parietal Cells | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 366). | |||
| REF 2 | Drug information of Clidinium, 2008. eduDrugs. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line. J Pharmacol Exp Ther. 1998 Feb;284(2):500-7. | |||
| REF 5 | Accidental acute clidinium toxicity. Emerg Med J. 2009 Jun;26(6):460. | |||
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