Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Q1UR
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| Former ID |
DIB013738
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| Drug Name |
TIAPAFANT
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| Synonyms |
PCA-4248; 2,4,6-Trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-(2-phenylthio)ethyl diester
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| Drug Type |
Small molecular drug
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| Indication | Sepsis [ICD-11: 1G40-1G41; ICD-10: R57.2; ICD-9: 785.52] | Terminated | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H23NO4S
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| Canonical SMILES |
CC1C(=C(NC(=C1C(=O)OCCSC2=CC=CC=C2)C)C)C(=O)OC
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| InChI |
1S/C19H23NO4S/c1-12-16(18(21)23-4)13(2)20-14(3)17(12)19(22)24-10-11-25-15-8-6-5-7-9-15/h5-9,12,20H,10-11H2,1-4H3
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| InChIKey |
DHCNAWNKZMNTIS-UHFFFAOYSA-N
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| CAS Number |
CAS 123875-01-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5601115, 8152884, 11120345, 11120833, 11121321, 11121682, 11122162, 11362748, 11365310, 11367872, 11370767, 11370768, 11373473, 11376034, 14779097, 26751776, 26751777, 29223784, 47290935, 47959527, 50104463, 51958183, 57322404, 58005752, 81093348, 85087783, 85788284, 89364513, 92310033, 99300945, 99302465, 103330468, 103828650, 104307165, 106157682, 117583461, 126407971, 135084228, 135515809, 135698036, 143556218, 144087360, 162022682, 162105869, 162273725, 162781980, 169957901, 178102701, 204362274, 215667297
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| ChEBI ID |
CHEBI:91615
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Platelet-activating factor receptor (PTAFR) | Target Info | Antagonist | [3], [4] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Staphylococcus aureus infection | ||||
| NetPath Pathway | IL5 Signaling Pathway | |||
| Leptin Signaling Pathway | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (q) signalling events | ||||
| Interferon gamma signaling | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Small Ligand GPCRs | ||||
| Interferon gamma signaling | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6080). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001989) | |||
| REF 3 | PCA-4248, a PAF receptor antagonist, inhibits PAF-induced phosphoinositide turnover. Eur J Pharmacol. 1995 Aug 15;290(3):183-8. | |||
| REF 4 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | |||
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