Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Q3SU
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| Drug Name |
Benzimidazole and imadazopyridine carboximidamide compound 1
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| Synonyms |
PMID29473428-Compound-23
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H20ClF3N6O2
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| Canonical SMILES |
COC1CN(C1)CCNC2=NC3=C(N2)C(=CC(=C3F)F)C(=NC4=CC(=C(C=C4)F)Cl)NO
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| InChI |
1S/C20H20ClF3N6O2/c1-32-11-8-30(9-11)5-4-25-20-27-17-12(7-15(23)16(24)18(17)28-20)19(29-31)26-10-2-3-14(22)13(21)6-10/h2-3,6-7,11,31H,4-5,8-9H2,1H3,(H,26,29)(H2,25,27,28)
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| InChIKey |
DZOQWZPMCBWTQQ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Indoleamine 2,3-dioxygenase 1 (IDO1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Indoleamine 2,3-dioxygenase 1 (IDO1) | Target's Patent Info | [1] | |
| BioCyc | Superpathway of tryptophan utilization | |||
| Tryptophan degradation | ||||
| L-kynurenine degradation | ||||
| Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | ||||
| NAD de novo biosynthesis | ||||
| KEGG Pathway | Tryptophan metabolism | |||
| Metabolic pathways | ||||
| African trypanosomiasis | ||||
| NetPath Pathway | TSLP Signaling Pathway | |||
| IL5 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathwhiz Pathway | Tryptophan Metabolism | |||
| Reactome | Tryptophan catabolism | |||
| WikiPathways | Tryptophan metabolism | |||
| Metabolism of amino acids and derivatives | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. | |||
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