Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Q4GJ
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| Former ID |
DNC004776
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| Drug Name |
2-Pyridin-3-yl-benzo[h]chromen-4-one
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| Synonyms |
MLS000757116; CHEMBL177938; 1939-53-3; 2-(pyridin-3-yl)-4H-benzo[h]chromen-4-one; NSC283845; 2-pyridin-3-ylbenzo[h]chromen-4-one; 2-Pyridin-3-yl-benzo[h]chromen-4-one; AC1L88Q3; CTK0E1147; DTXSID00314472; ZINC13143019; BDBM50159611; NSC-283845; SMR000449783; TX-011635; 4H-Naphtho[1,2-b]pyran-4-one, 2-(3-pyridinyl)-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H11NO2
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| Canonical SMILES |
C1=CC=C2C(=C1)C=CC3=C2OC(=CC3=O)C4=CN=CC=C4
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| InChI |
1S/C18H11NO2/c20-16-10-17(13-5-3-9-19-11-13)21-18-14-6-2-1-4-12(14)7-8-15(16)18/h1-11H
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| InChIKey |
RURRJHXFMININK-UHFFFAOYSA-N
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| CAS Number |
CAS 1939-53-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Non-homologous end-joining | |||
| Cell cycle | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
| Coregulation of Androgen receptor activity | ||||
| Class I PI3K signaling events mediated by Akt | ||||
| BARD1 signaling events | ||||
| Reactome | Nonhomologous End-Joining (NHEJ) | |||
| WikiPathways | DNA Damage Response | |||
| Non-homologous end joining | ||||
| FAS pathway and Stress induction of HSP regulation | ||||
| Cytosolic sensors of pathogen-associated DNA | ||||
| Retinoblastoma (RB) in Cancer | ||||
| Prostate Cancer | ||||
| Double-Strand Break Repair | ||||
| Cell Cycle | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. | |||
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