Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Q5MQ
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| Former ID |
DNCL003107
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| Drug Name |
Tasimelteon
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| Synonyms |
Tasimelteon; 609799-22-6; Hetlioz; VEC-162; BMS-214778; VEC 162; UNII-SHS4PU80D9; BMS 214778; SHS4PU80D9; CHEBI:79042; N-{[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl}propanamide; Tasimelteon [USAN:INN]; tasimelteonum; N-([(1r,2r)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl)propanamide; N-[[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl]propanamide; N-(((1R,2R)-2-(2,3-Dihydro-1-benzofuran-4-yl)cyclopropyl)methyl)propanamide; Hetlioz (TN); Tasimelteon (USAN/INN); SCHEMBL3505912; GTPL7393
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| Drug Type |
Small molecular drug
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| Indication | Insomnia [ICD-11: 7A00-7A0Z] | Approved | [1], [2] | |
| Company |
Vanda Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C15H19NO2
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| Canonical SMILES |
CCC(=O)NCC1CC1C2=C3CCOC3=CC=C2
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| InChI |
1S/C15H19NO2/c1-2-15(17)16-9-10-8-13(10)11-4-3-5-14-12(11)6-7-18-14/h3-5,10,13H,2,6-9H2,1H3,(H,16,17)/t10-,13+/m0/s1
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| InChIKey |
PTOIAAWZLUQTIO-GXFFZTMASA-N
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| CAS Number |
CAS 609799-22-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
15221060, 22609327, 40334994, 46387835, 78704256, 92722464, 96026068, 126627315, 126662442, 128966262, 135253193, 137132834, 137788131, 141198068, 160676375, 164777429, 165238001, 178103965, 180371725, 198968673, 198994004, 223444257, 223675953, 225045086, 229516194, 241124240, 251971356, 252552922, 252671867
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| ChEBI ID |
CHEBI:79042
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| ADReCS Drug ID | BADD_D02118 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Melatonin receptor type 1A (MTNR1A) | Target Info | Agonist | [1] |
| Melatonin receptor type 1B (MTNR1B) | Target Info | Agonist | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Circadian entrainment | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7393). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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