Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Q7OA
|
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| Former ID |
DIB011693
|
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| Drug Name |
HydrocoDex
|
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| Synonyms |
Acetaminophen/dextromethorphan
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|
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| Indication | Pain [ICD-11: MG30-MG3Z] | Terminated | [1], [2] | |
| Company |
Endo Pharmaceuticals
|
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor sigma 1 (OPRS1) | Target Info | Modulator | [1], [2] |
| Serotonin transporter (SERT) | Target Info | Modulator | [1], [2] | |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | 5HT1 type receptor mediated signaling pathway | |||
| 5HT2 type receptor mediated signaling pathway | ||||
| 5HT3 type receptor mediated signaling pathway | ||||
| 5HT4 type receptor mediated signaling pathway | ||||
| WikiPathways | Monoamine Transport | |||
| SIDS Susceptibility Pathways | ||||
| NRF2 pathway | ||||
| Synaptic Vesicle Pathway | ||||
| Serotonin Transporter Activity | ||||
| miR-targeted genes in squamous cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. | |||
| REF 2 | Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6. | |||
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