Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0QM0D
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| Drug Name |
Oxotetrahydro-2-H-furo[3.2-b]pyrrol-4(5-H)-yl derivative 1
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| Synonyms |
PMID27998201-Compound-14
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Patented | [1] | |
| Company |
AMURA THERAPEUTICS LIMITED QUIBELL, Martin WATTS, John, Paul FLINN, Nicholas, Sean
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H27ClN4O4
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| Canonical SMILES |
C1CCC(CC1)C(C(=O)N2CC(C3C2C(=O)CO3)Cl)NC(=O)C4=CC=CC(=C4)C5=CNN=C5
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| InChI |
1S/C24H27ClN4O4/c25-18-12-29(21-19(30)13-33-22(18)21)24(32)20(14-5-2-1-3-6-14)28-23(31)16-8-4-7-15(9-16)17-10-26-27-11-17/h4,7-11,14,18,20-22H,1-3,5-6,12-13H2,(H,26,27)(H,28,31)/t18-,20-,21+,22+/m0/s1
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| InChIKey |
CTSFUIJCUAXDOL-VXSCBNMQSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cathepsin K (CTSK) | Target Info | Inhibitor | [1] |
| Cathepsin S (CTSS) | Target Info | Inhibitor | [1] | |
| Target's Patent Info | Cathepsin K (CTSK) | Target's Patent Info | [1] | |
| Cathepsin S (CTSS) | Target's Patent Info | [1] | ||
| KEGG Pathway | Lysosome | |||
| Osteoclast differentiation | ||||
| Toll-like receptor signaling pathway | ||||
| Rheumatoid arthritis | ||||
| Phagosome | ||||
| Antigen processing and presentation | ||||
| Tuberculosis | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| RANKL Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| Leptin Signaling Pathway | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| Trafficking and processing of endosomal TLR | ||||
| MHC class II antigen presentation | ||||
| Endosomal/Vacuolar pathway | ||||
| Assembly of collagen fibrils and other multimeric structures | ||||
| WikiPathways | RANKL/RANK Signaling Pathway | |||
| Osteoclast Signaling | ||||
| Class I MHC mediated antigen processing & presentation | ||||
| Trafficking and processing of endosomal TLR | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. | |||
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