Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0QT3C
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| Drug Name |
Azole derivative 6
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| Synonyms |
PMID25470667-Compound-Figure5-10
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| Drug Type |
Small molecular drug
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| Company |
MERCK SHARP &amDOHME CORP. DEVITA, Robert, J. YU, Yang LIU, Jian HE, Shuwen KRIKORIAN, Arto, D. MILLER, Daniel, J. WU, Zhicai YANG, Ginger Xu-Qiang HONG, Quingmei LAI, Zhong ZORN, Nicolas TING, Pauline, C
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| Structure |
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Download2D MOL |
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| Formula |
C23H19ClFN3O3
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| Canonical SMILES |
CC(C)(COC1=NC=C(C=C1)C2=CC(=C(C=C2)C3=NC4=C(N3)C=C(C=C4)Cl)F)C(=O)O
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| InChI |
1S/C23H19ClFN3O3/c1-23(2,22(29)30)12-31-20-8-4-14(11-26-20)13-3-6-16(17(25)9-13)21-27-18-7-5-15(24)10-19(18)28-21/h3-11H,12H2,1-2H3,(H,27,28)(H,29,30)
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| InChIKey |
VDSPJLXCWHECIK-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Diacylglycerol acyltransferase 1 (DGAT1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Diacylglycerol acyltransferase 1 (DGAT1) | Target's Patent Info | [1] | |
| BioCyc | Triacylglycerol biosynthesis | |||
| KEGG Pathway | Glycerolipid metabolism | |||
| Retinol metabolism | ||||
| Metabolic pathways | ||||
| Fat digestion and absorption | ||||
| Pathwhiz Pathway | Retinol Metabolism | |||
| Reactome | Acyl chain remodeling of DAG and TAG | |||
| Triglyceride Biosynthesis | ||||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Statin Pathway | ||||
| Triacylglyceride Synthesis | ||||
| Glycerophospholipid biosynthesis | ||||
| Fatty acid, triacylglycerol, and ketone body metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. | |||
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