Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0R4IT
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| Drug Name |
Heterocyclic-fused piperazine derivative 1
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| Synonyms |
PMID27724045-Compound-5
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| Drug Type |
Small molecular drug
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| Company |
GSK
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H11ClF3N5OS
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| Canonical SMILES |
C1CN2C(=NN=C2C3=CSC=N3)CN1C(=O)C4=C(C(=CC=C4)C(F)(F)F)Cl
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| InChI |
1S/C16H11ClF3N5OS/c17-13-9(2-1-3-10(13)16(18,19)20)15(26)24-4-5-25-12(6-24)22-23-14(25)11-7-27-8-21-11/h1-3,7-8H,4-6H2
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| InChIKey |
BDKXTJZVSCTDFF-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | P2X purinoceptor 7 (P2RX7) | Target Info | Antagonist | [1] |
| Target's Patent Info | P2X purinoceptor 7 (P2RX7) | Target's Patent Info | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Reactome | The NLRP3 inflammasome | |||
| WikiPathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. | |||
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