Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0R9ON
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| Former ID |
DNC000960
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| Drug Name |
MR-889
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| Synonyms |
Midesteine; Midesteine [INN]; Midesteinum [INN-Latin]; Midesteina [INN-Spanish]; MR-889; 94149-41-4; MR 889; CHEMBL1808549; 2-(Thiophen-2-ylcarbonylthio)-N-(2-oxo-2,3,4,5-tetrahydrothiophen-3-yl)propionamide; 2-Thiophenecarbothioic acid, S-(1-methyl-2-oxo-2-((tetrahydro-2-oxo-3-thienyl)amino)ethyl) ester; C12H13NO3S3; Midesteinum; Midesteina; 2-Thiophenecarbothioic acid, S-ester with (+-)-2-mercapto-N-(tetrahydro-2-oxo-3-thienyl)propionamide; SCHEMBL724755; AC1L242H; CTK3I7550; MR889; BDBM50349435; SB19618; LS-152918
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| Drug Type |
Small molecular drug
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| Indication | Phlegmy cough [ICD-11: SA80-SA8Z; ICD-10: J00-J99] | Discontinued in Phase 3 | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C12H13NO3S3
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| Canonical SMILES |
CC(C(=O)NC1CCSC1=O)SC(=O)C2=CC=CS2
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| InChI |
1S/C12H13NO3S3/c1-7(19-12(16)9-3-2-5-17-9)10(14)13-8-4-6-18-11(8)15/h2-3,5,7-8H,4,6H2,1H3,(H,13,14)
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| InChIKey |
MKTVMEMIKNBVHI-UHFFFAOYSA-N
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| CAS Number |
CAS 94149-41-4
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neutrophil elastase (NE) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Transcriptional misregulation in cancer | |||
| Systemic lupus erythematosus | ||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||
| C-MYB transcription factor network | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||
| Human Complement System | ||||
| Degradation of collagen | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003709) | |||
| REF 2 | Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. | |||
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