Drug Information
Drug General Information | Top | |||
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Drug ID |
D0RV0O
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Drug Name |
PMID29334795-Compound-23
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Drug Type |
Small molecular drug
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Indication | Schizophrenia [ICD-11: 6A20] | Patented | [1] | |
Company |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED WANG, Rong LU, HongtaGLAXO GROUP LIMITED BAMFORD, Mark, James DEAN, David, Kenneth SEHMI, Sanjeet, Singh WILSON, David, Matthew WITHERINGTON, Jason
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Structure |
Download2D MOL |
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Formula |
C23H27N3O2
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Canonical SMILES |
C1CC(C1)N2CCC3=C(CC2)C=C(C=C3)OC4=NC=C(C=C4)N5CCCC5=O
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InChI |
1S/C23H27N3O2/c27-23-5-2-12-26(23)20-7-9-22(24-16-20)28-21-8-6-17-10-13-25(19-3-1-4-19)14-11-18(17)15-21/h6-9,15-16,19H,1-5,10-14H2
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InChIKey |
YFRBKEVUUCQYOW-UHFFFAOYSA-N
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CAS Number |
CAS 720691-69-0
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Histamine H3 receptor (H3R) | Target Info | Inverse agonist | [1] |
Target's Patent Info | Histamine H3 receptor (H3R) | Target's Patent Info | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Reactome | Histamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Monoamine Transport | |||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. |
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