Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S2ZR
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| Former ID |
DNC006997
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| Drug Name |
JWH-147
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| Synonyms |
JWH-147; 914458-20-1; CHEMBL374982; (1-hexyl-5-phenyl-1H-pyrrol-3-yl)(naphthalen-1-yl)methanone; SCHEMBL15435604; JWH 147; DTXSID00658823; FRMYAMAGHYHNKF-UHFFFAOYSA-N; JWH-147"; ZINC36294592; BDBM50192588; AKOS015950991; AB1006809; FT-0669208; 1-Hexyl-2-phenyl-4-(1-naphthoyl)pyrroleJWH-147; 1-Hexyl-2-phenyl-4-(1-naphthoyl)pyrrole JWH-147; (1-Hexyl-5-phenyl-1H-pyrrol-3-yl)-1-naphthalenylmethanone
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C27H27NO
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| Canonical SMILES |
CCCCCCN1C=C(C=C1C2=CC=CC=C2)C(=O)C3=CC=CC4=CC=CC=C43
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| InChI |
1S/C27H27NO/c1-2-3-4-10-18-28-20-23(19-26(28)22-13-6-5-7-14-22)27(29)25-17-11-15-21-12-8-9-16-24(21)25/h5-9,11-17,19-20H,2-4,10,18H2,1H3
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| InChIKey |
FRMYAMAGHYHNKF-UHFFFAOYSA-N
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| CAS Number |
CAS 914458-20-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cannabinoid receptor 1 (CB1) | Target Info | Inhibitor | [1] |
| Cannabinoid receptor 2 (CB2) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Rap1 signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | ||||
| Panther Pathway | Endogenous cannabinoid signaling | |||
| Pathway Interaction Database | N-cadherin signaling events | |||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| BDNF signaling pathway | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. | |||
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